Siteman Cancer Center
Center for Advanced Medicine
4921 Parkview Place, Floor LL
St. Louis, MO 63110
Washington University School of Medicine
4511 Forest Park, Campus Box 8224
St. Louis, MO 63110
Areas of Clinical Interest:
Radiation oncology, breast cancer
Radiation Oncology, 1997
Medical Degree: University Of London, UK
St. Louis Children's Hospital
Major or Recent Publications/Awards
Honors and Awards:
2001 - Elected Chair of Gordon Conference, Radiation Oncology, for 2007
1996 - Elected Fellow of the Royal College of Physicians of Edinburgh
1988 - Rohan Williams Medal, Royal College of Radiologists, U.K.
1981 - Rosenheim Award, University College, London
1977 - Glaxo Prize, University College, London
1976 - Sidgwick Essay Prize, Corpus Christi College, Oxford
1976 - Corpus Christi College Award, Corpus Christi College, Oxford
Selected Publications :
Wang, H, Wang, H, POWELL, S.N., Iliakis, G and Wang, Y. ATR affecting
cell radio-sensitivity is dependent on homologous recombination repair but
independent of nonhomologous end joining. Cancer Res., 2004 64 (19): 7139-43.
Romanova, L., Willers, H., Blagosklonny, M. and POWELL, S.N. The interaction
of p53 with replication protein A mediates suppression of homologous recombination.
Oncogene, e-pub Oct 18th, 2004.
Fabbro M, Savage K, Hobson K, Deans AJ, POWELL SN, McArthur GA, Khanna
KK. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and
a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem.
2004 Jul 23;279(30):31251-8.
Feng, Z., Kachnic, L.A., Zhang, J., POWELL, S.N. and Xia, F. BRCA1 nuclear
export after DNA damage is p53-dependent. J. Biol. Chem., 2004 Jul 2;279(27):28574-84.
Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, POWELL
SN, Xia F. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break
repair. Mol Cell Biol. 2004 Jan;24(2):708-18.
Lawenda, B.D., Taghian A.G., Kachnic, L.A., Hamdi, H., Smith, B.L., Gadd,
M.A., Mauceri, T. and POWELL, S.N. A Dose-Volume Analysis of Radiation Therapy
for T1N0 Invasive Breast Cancer treated by Local Excision and Partial Breast
Irradiation by Low-Dose Rate Interstitial Implant. Int J. Radiat. Oncol.
Biol. Phys, 2003, 56 (3) 671-680.
POWELL, S.N., Willers, H. and Xia, F. BRCA2 keeps Rad51 in line. High-fidelity
homologous recombination prevents breast and ovarian cancer? Mol. Cell.
Shannon KM, Lubratovich ML, Finkelstein DM, Smith BL, Powell SN, Seiden
MV. Model-based predictions of BRCA1/2 mutation status in breast carcinoma
patients treated at an academic medical center. Cancer. 2002 Jan 15;94(2):305-13.
Taghian, A.G., Assaad, S.I., Kuter,I., Younger,J.R., Schoenthaler,R.,
Roche, M. and POWELL, S.N. Increased Risk of Radiation Pneumonitis in Patients
with Breast Cancer Treated by Combination Chemotherapy Including Paclitaxel
Given Concurrently or Sequentially with Radiation Therapy. JNCI, 2001, 93(23),
Xia, F., Taghian, D.G., McDonough, K.M., DeFrank, J.S., Willers, H., Iliakis,
G., POWELL, S.N. Deficiency of the human BRCA2 leads to impaired homologous
recombination but maintains normal non-homologous end-joining. Proceedings
of the National Academy of Sciences, 2001, 98(15) 8644-9.
Wang H, Zeng ZC, Bui TA, DiBiase SJ, Qin W, Xia F, POWELL SN, and Iliakis
GN. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded
breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Res. 2001,
Willers, H., McCarthy, E.E., Wu, B., Wunsch, H., Tang, W., Taghian, D,
Xia, F. and POWELL, SN. P53 can suppress Homologous Recombination in Rodent
Embryonic Fibroblasts Despite Loss of G1/S Cell Cycle Checkpoint Control
and Non-Specific DNA Binding Activity. Oncogene, 19: 632-639, 2000.
Kachnic, LA, Wu, B, Wunsch, H, Tang, W, DeFrank, JS,. and POWELL, SN.
The Ability of p53 to activate downstream genes p21(WAF1/cip1) and MDM2,
and cell cycle arrest following DNA damage is delayed and attenuated in
scid cells, deficient in the DNA-dependent protein kinase. J. Biol Chem.,
274 (19); 13111-13117, 1999.
Morris, M and POWELL, SN. Radiation therapy in the setting of collagen
vascular disease. J.Clin.Oncol. 15(7): 2728-35, 1997
Mekeel, KL, Tang, W., Kachnic, LA, Luo, C-M, DeFrank, JS and POWELL, SN.
Inactivation of p53 Results in High Rates of Homologous Recombination. Oncogene
14: 1847-1857, 1997.
Luo,C-M, Tang,W, Anne,PR, McKeel,KL, DeFrank JD and POWELL,SN. High frequency
and error-prone recombination in ataxia-telangiectasia cells. J. Biol. Chem.
271: 4497-4503, 1996.
POWELL,SN, DeFrank,JS, Connell,P, Eogan,M, Preffer, F, Dombkowski, D,
Tang,W and Friend,SH. Differential sensitivity of p53- and p53+ cells to
caffeine-induced radiosensitization and override of G2 delay. Cancer Research
55: 1643-1648, 1995.