The Radiation Oncology Department of the Mallinckrodt Institute of Radiology, Washington University School of Medicine, has a long history of innovation and development. Over the years we have been among the leaders in the development and clinical implementation of most of the major technical breakthroughs in Radiation Oncology. This has extended from the early days of high energy linear accelerators and the first desktop treatment planning computers through 3-dimensional treatment planning and intensity-modulated radiotherapy today. Researchers in the Cancer Biology Section of the Radiation Oncology Department have been at the forefront in elucidating the mechanisms of radiation biology including the effects of hyperthermia (heat treatments) on radiation sensitivity. In recent years we have also developed a series of collaborative research projects with our colleagues in diagnostic radiology building on new opportunities to image important biologic functions non invasively.
In addition to basic research, we are participating in a wide number of clinical trials, bringing important innovations to our patients. We are active participants in national cooperative groups, including the Radiation Therapy Oncology Group (RTOG), Cancer and Leukemia Group B (CALGB), Gynecologic Oncology Group (GOG), and the Pediatric Oncology Group (POG). In collaboration with our colleagues elsewhere in the Siteman Cancer Center, we have a large number of intramural protocolos investigating new issues in cancer management.