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Heping Yan, MD

Assistant Professor of Radiation Oncology

Phone314-362-9774

Emailyan.h@wustl.edu

Education

  • MD: West China University of Medical Sciences, Sichuan, China (1979)
  • MS, Immuno-parasitology: West China University of Medical Sciences, Sichuan, China (1982)

Biography

Heping Yan, MD is Assistant Professor in the Cancer Biology Division of the Department of Radiation Oncology. He earned both his medical degree and his master’s degree in Immuno-Parasitology at West China University of Medical Sciences. His current research focuses on the targeting of ionizing radiation inducible antigens for human cancer treatment. Ionizing radiation is a treatment tool for many types of human cancers that can kill tumor cells and elicit phenotypic changes in the cells. Thus, the molecules (neo-antigen) are expressed on the surface of irradiated tumor cells. The neo-antigen can be served as tumor cell targeted. Antibody is a tool to target these neo-antigens through antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cell-mediated cytotoxicity (ADCC) by receptors on dendritic cells, NK cells or other kinds of T cells, or complement activation to kill tumor cells. Antibodies can also deliver radioactive materials and slip powerful drugs into tumor cells or deliver an exotoxin to kill tumor cells. Dr. Heping Yan has over 20 years of experience in producing these kinds of monoclonal antibodies (McAb) using a hybridoma technique and single chain fragment variable (ScFv) antibodies from phage and yeast displayed library, and studying a variety molecules including these IR inducible neo-antigens on surface of tumor cells. He is very experienced in immune-detection methods and human tumor mouse xenograft models in vitro and in vivo imaging study. He co-authored a book published by Beijing Publishing house. He has successfully made antibodies such as anti Tip1, GRP78, CRT, P-selectin and TAF15 for research and pre-clinical trial application.

Publications

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