Aadel Chaudhuri, MD, PhD

Assistant Professor of Radiation Oncology

  • Phone: 314-273-2931

Education

  • BS, Electrical Engineering & Computer Science, Biology: Massachusetts Institute of Technology (Cambridge, MA) (2004)
  • PhD, Biology: California Institute of Technology (Pasadena, CA) (2011)
  • MD: Stanford University (Stanford, CA) (2013)
  • Internship: Scripps Mercy Hospital (San Diego, CA) (2014)
  • Residency, Radiation Oncology: Stanford University (Stanford, CA) (2018)
  • Post-doctoral research, Applied Genomics & Precision Medicine: Stanford University (Stanford, CA) (2018)

Recognition

  • Barry M. Goldwater Scholarship (2003-2004)
  • Tau Beta Pi Engineering Honor Society (2004)
  • MIT Ilona Karmel Award for Engineering Writing (2004)
  • Howard Hughes Medical Institute (HHMI) Medical Research Fellowship (2006-2007)
  • Alpha Omega Alpha (AOA) Carolyn Kuckein Research Award (2007)
  • American Medical Association (AMA) Seed Grant Award (2007)
  • California Institute of Technology Excellence in Teaching Award (2008)
  • National Science Foundation (NSF) Graduate Research Fellowship (2008-2011)
  • Paul and Daisy Soros Fellowship (2011-2013)
  • AACR-GlaxoSmithKline Outstanding Clinical Scholar Award (2014)
  • RSNA Resident/Fellow Research Grant (2015-2016)
  • ASTRO Annual Meeting Abstract Award and Honorarium (2016)
  • Abstract selected for presentation at Best of ASTRO Meeting: “CAPP-Seq circulating tumor DNA analysis for early detection of tumor progression after definitive radiotherapy for lung cancer.” American Society for Radiation Oncology (2016)
  • Malcolm Bagshaw Research Seminar Award for Top Presentation (2016)
  • American Board of Radiology (ABR) Holman Research Pathway (2016-2017)
  • ASTRO Resident Clinical/Basic Science Research Award and Honorarium (2017)
  • Abstract selected for presentation at Best of ASTRO Meeting: “Circulating tumor DNA analysis during radiotherapy for localized lung cancer predicts treatment outcome.” American Society for Radiation Oncology (2017)
  • ASCO Conquer Cancer Foundation Merit Award and Travel Grant (2017)
  • Stanford Society for Physician Scholars (SSPS) Research Grant (2017)
  • ASCO Young Investigator Award (2017-2018)
  • RSNA Resident/Fellow Research Grant (2017-2018)
  • RSNA Roentgen Research Award (2018)
  • Chairperson, AACR Education Session “NGS Methods for Disease Monitoring” (2018)

Clinical Interests

  • Thoracic Oncology
  • Head and Neck Oncology
  • Gastrointestinal Oncology
  • Stereotactic Body Radiotherapy

Biography

Aadel Chaudhuri, MD, PhD, is an assistant professor in radiation oncology and a physician-scientist who treats lung cancer. Dr. Chaudhuri completed his medical degree at Stanford, PhD at Caltech, and undergraduate degrees at MIT. He completed his residency in radiation oncology at the Stanford Cancer Institute, where he did postdoctoral work under the Holman Pathway with Dr. Maximilian Diehn and Dr. Ash Alizadeh, showing that circulating tumor DNA (ctDNA) can serve as a biomarker for molecular residual disease (MRD) after curative-intent lung cancer treatment. He joined the faculty at Washington University in 2018, where he is continuing this line of research.

Research

Dr. Chaudhuri’s research focuses on cell-free nucleic acids, and specifically on the identification and measurement of circulating tumor DNA (ctDNA) as a cancer biomarker. In a paper published in Cancer Discovery in 2017, he and his colleagues showed that they could measure ctDNA in the blood of non-metastatic lung cancer patients shortly after completing treatment and months before standard-of-care CT imaging. Post-treatment ctDNA detection served as a biomarker for ultimate disease relapse and survival, and genomic analyses of the ctDNA identified candidacy for precision medicine drugs including tyrosine kinase inhibitors and immune checkpoint inhibitors. Dr. Chaudhuri is interested in applying these findings to clinical practice, exploring ctDNA as a biomarker in other malignancies, and using ctDNA as a tool to monitor responses to radiotherapy and immunotherapy.

Publications

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Related Links

Chaudhuri Lab