Kareem Azab, PhD conducts multi-disciplinary translational research with a focus on treatment and imaging of cancer, including hematologic malignancies and solid tumors. He works intensively on understanding the biological mechanisms of cancer progression and metastasis, development of novel drugs, targeted delivery of therapeutic agents (from nano-sized systems up to medical devices), and on developing patient-derived, tissue engineered pre-clinical models to study cancer.
We are interested in understanding the biological mechanisms of proliferation and metastasis in cancer, including multiple myeloma, lymphoma and others. We are interested in understanding the mechanism involved in cell trafficking of cancer cells during proliferation metastasis.
We study the use of conjugated copolymers to increase the specificity of chemo and radiotherapy. We are interested both radio and chemotherapeutic agents, and we have a special interest in Boron Neutron Capture Therapy (BNCT), which is referred to the radiation generated from the capture reaction of thermal or epithermal neutrons by 10Boron isotopes.
Localized Drug Delivery
Our goal is to develop drug delivery systems that will increase the effectivity and reduce the side effects of existing the treatments. We focus on local delivery approaches, where we biodegradable medical implants for localized and high dose delivery of therapeutic agents in the tumor bed, and decrease the dose to all other parts of the body.
Our goal is to develop a 3D-Tissue Engineered Bone Marrow (3DTEBM) which provides an improved model for understanding tumor biology and drug resistance of MM in the context of the malignant BM microenvironment; and it provides personalized prediction of therapeutic efficacy in individual MM patients.
Our goal is to develop nano-particles with different sizes (70-250nm) with different loads including chemotherapy, cell signaling inhibitors, radioisotopes (for therapy and imaging), and fluorescent dyes for imaging. The nano-particles can be targeted using different targeting moieties (such as antibodies, receptors and ligands) to specifically target a variety of tumor types including multiple myeloma, lymphoma, leukemia; as well as brain, lung cervix, breast. head and neck lung, and other cancers.