Clinical Research

The clinical and physics research programs center on the development of new technology. Faculty within the department participate in four general categories of clinical research:  patient oriented research to improve post-therapy outcomes; procedure oriented research to advance radiation therapy delivery; discovery research for predictive biomarkers; mechanisms for drug development.

Current clinical research is focused on adaptive radiotherapy, image guided radiotherapy, and functional imaging using PET and MRI.  Investigators study cancer biomarkers and tissue injury that result from radiotherapy.  Clinicians partner with industry to develop new technology including the single room proton therapy system, MR imaging guided therapy, and state of the art brachytherapy.

Clinical trials

The Department of Radiation Oncology participates in a wide number of clinical trials, bringing important innovations to our patients.  We are active participants in national cooperative groups, including the Radiation Therapy Oncology Group (RTOG), Cancer and Leukemia Group B (CALGB), Gynecologic Oncology Group (GOG), and the Children’s Oncology Group (COG).  In collaboration with our colleagues in the Siteman Cancer Center, we have a large number of intramural protocols investigating new cancer management.

The department is recognized as a national leader in radiation oncology clinical trials, and ranks as the highest academic accrual site for cooperative group therapeutic trials, with 273 total treatment intervention accruals during the 2015-16 grant year as indicated by the Lead Academic Participating Site Organization (LAPS).

Learn more about current clinical trials »


The Deparment of Radiation Oncology is a participant in the Pediatric Proton Consortium Registry.